Ayurvedic Medicinal Plants and Plant-Derived Extracellular Vesicles: Current Evidence and Future Perspectives

The document explores the potential of plant-derived extracellular vesicles (PDEVs) from Ayurvedic medicinal plants as a modern approach to delivering bioactive compounds with enhanced stability and targeted uptake. PDEVs offer advantages such as easy isolation, low cost, and safety, and they can transport therapeutic agents to enhance bioavailability and target damaged cells. The review highlights the synergy between traditional Ayurvedic medicine and modern nanomedicine, proposing PDEVs as a bridge between the two. Notably, garlic-derived exosomes have shown efficacy in promoting hair growth through the Wnt/β-Catenin pathway, while Ashwagandha-derived exosome-like nanoparticles significantly promote human hair growth by stimulating VEGF-A production. The document emphasizes the need for further research and standardization of isolation techniques to fully realize the therapeutic potential of PDEVs in treating conditions like hair loss, cancer, and inflammatory diseases.