Baricitinib in the Management of Severe Alopecia Areata: A Report of Two Cases with Sustained Clinical Response

October 2025 in “ Cureus ”

Youssef Zemmez, Mohamed-amine Ennaciri, Rachid Frikh, Naoufal Hjira

baricitinib alopecia areata SALT score hair regrowth

TLDR Baricitinib effectively regrows hair in severe alopecia areata cases.

Baricitinib, recently approved by the FDA for severe alopecia areata, has shown promise in treating this condition, as well as COVID-19 and rheumatoid arthritis. In a report of two cases, patients with severe alopecia areata (SALT score = 100) were treated with baricitinib, resulting in favorable outcomes and complete hair regrowth over a 12-month follow-up. The treatment is cost-effective, minimally invasive, and requires no postoperative management, though safety and clinical implications should be considered before widespread use.

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Research cited in this study

8 / 8 results

research From Mechanisms to Therapies: Current Advances and Breakthroughs in Alopecia Areata Immunopathology

3 citations , September 2025 in “Frontiers in Immunology”

JAK inhibitors are effective for treating moderate-to-severe alopecia areata.

Modern and Promising Strategies for Treatment of Alopecia in the United States: Clinical, Pharmacological, Marketing, Regulatory, SWOT Analysis

research Modern and Promising Strategies for Treatment of Alopecia in the United States: Clinical, Pharmacological, Marketing, Regulatory, SWOT Analysis

August 2025 in “SSP Modern Pharmacy and Medicine”

Effective alopecia treatments exist, but high costs and limited access remain challenges.

research Long-Term Real-World Outcomes of Baricitinib in Severe Alopecia Areata: A 104-Week Retrospective Analysis From a Single Institute

June 2025 in “The Journal of Dermatology”

Baricitinib is effective and safe for long-term treatment of severe alopecia areata.

research Strong Efficacy of Ritlecitinib 50 mg and Baricitinib 4 mg in Alopecia Areata, but Further Research Needed to Establish Superiority

1 citations , May 2025 in “Journal of the European Academy of Dermatology and Venereology”

Ritlecitinib and baricitinib are effective for alopecia areata, but more research is needed to determine which is better.

research Real-Life Effectiveness and Tolerance of Baricitinib for the Treatment of Severe Alopecia Areata with 1-Year Follow-Up Data

September 2023 in “Dermatology and Therapy”

Baricitinib effectively regrows hair in most people with severe alopecia, especially those with patchy hair loss, but hair may fall out again if treatment stops.

research Alopecia Areata: An Updated Review for 2023

91 citations , May 2023 in “Journal of Cutaneous Medicine and Surgery”

Alopecia Areata affects 2% globally, with treatments like essential oils, garlic, and JAK inhibitors showing promise, but more research is needed.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

Baricitinib was effective in treating alopecia areata in two major trials.

research Alopecia Areata: Current Situation and Perspectives

34 citations , October 2017 in “Archivos Argentinos De Pediatria”

Alopecia Areata is a complex, unpredictable autoimmune hair loss condition with limited treatment options and a significant psychological impact.

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6 / 19 results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Pelage are going to do two phase 3 trials for PP405. How long will it take to complete two phase 3 trials?

in Chat 45 upvotes 2 months ago

Pelage plans to conduct two Phase 3 trials for PP405, a new hair loss treatment, which may take about a year to complete. Users discuss various hair loss treatments, including pyrilutamide, minoxidil, finasteride, and clascoterone, with some expressing impatience over the lengthy trial process compared to faster drug approvals like the COVID vaccine.

community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

in Research/Science 3 years ago

Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.

community Olumiant active ingredient Baricitinib

in Research/Science 1 upvotes 3 years ago

The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 3 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Anyone heard of or have experience using baricitinib?

in Research/Science 1 upvotes 2 years ago

The conversation is about baricitinib, a medicine that can help with hair loss, and why it isn't more popular or widely discussed. No specific experiences with the treatment were shared.

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6 / 665 results

research Efficacy of Baricitinib in Patients with Various Degrees of Alopecia Areata Severity: Post-Hoc Analysis from BRAVE AA1 and BRAVE AA2

1 citations , September 2023 in “Dermatology and Therapy”

Baricitinib helps improve hair growth in severe alopecia, with better results in less severe cases and higher doses working faster.

research The Evaluation of JAK Inhibitors on Effect and Safety in Alopecia Areata: A Systematic Review and Meta-Analysis of 2018 Patients

4 citations , June 2023 in “Frontiers in immunology”

JAK inhibitors help hair regrowth in alopecia areata but have a high risk of side effects.

research Janus Kinase Inhibitors for Alopecia Areata: A Narrative Review

2 citations , June 2023 in “Indian journal of dermatology, venereology, and leprology”

Janus kinase inhibitors can regrow hair in alopecia areata but may cause side effects and hair loss may return if treatment stops.

research Alopecia Areata: Diagnostic and Therapeutic Recommendations of the Polish Society of Dermatology. Part 2: Treatment

1 citations , January 2023 in “Przegląd Dermatologiczny”

The Polish Society of Dermatology recommends treatments for alopecia areata that vary by severity, including topical and systemic medications, with long-term maintenance important for management.

research Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Diseases

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New understanding and treatments for hair loss are improving, but more research is needed.

research An Update in the Management of Alopecia Areata

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New treatments for alopecia areata show promise, but more research is needed to confirm their effectiveness.