<b>Finasteride-Induced Neuropsychiatric Reactions Are Well Established</b>

The document discusses the strong evidence linking finasteride, a treatment for androgenetic alopecia (AGA), to neuropsychiatric reactions, including depression and increased suicide risk. Despite some studies showing no impact of AGA on depression, finasteride has been associated with mood worsening and suicidal thoughts, as recognized by the European Medicines Agency. The evidence is supported by multiple studies across different countries, satisfying criteria for causality such as temporality, reversibility, and consistency. The rarity of suicide cases makes it difficult for clinicians to recognize the issue, and depressive symptoms are often attributed to life events rather than the drug. The document suggests that non-pharmacological treatments may be safer alternatives and highlights the economic impact of finasteride-induced depression, calling for regulatory action.