Improvement of Female Pattern Hair Loss with Bicalutamide: A Time-Dependent Process

    August 2025 in “ JAAD International ”
    Rocío Gil‐Redondo, David Saceda‐Corralo, Juan Jiménez-Cahué, Sergio Vañó‐Galván
    TLDR Bicalutamide may reduce hair shedding in women but needs longer trials to confirm its effectiveness.
    The study by da Silva et al. evaluated the effects of bicalutamide 25 mg/day combined with minoxidil 1 mg/day versus minoxidil alone for female pattern hair loss (FPHL) in a randomized double-blind trial with 32 participants per group. While no significant improvement in hair density was observed with the addition of bicalutamide, there was a reduction in hair shedding and facial hypertrichosis. The study's short follow-up period of 24 weeks may not be sufficient to detect changes in hair density, as antiandrogen treatments often require longer durations to show efficacy. Bicalutamide, a selective androgen receptor antagonist, may be a potential alternative for FPHL cases where other antiandrogens are poorly tolerated. The study suggests that longer-term trials are needed to better assess the efficacy of bicalutamide in improving hair density.
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