Bio-Nanovesicle-Based Approaches for Hair and Skin Regeneration: An Updated Concise Review
March 2026
in “
Cells
”
bio-nanovesicles BNVs hair regeneration skin regeneration miRNAs proteins growth factors extracellular vesicles exosomes microvesicles engineered nanovesicles Wnt/β-catenin pathway PI3K/AKT pathway MAPK/ERK pathway TGF-β/BMP pathway angiogenesis alopecia follicular miniaturization immune dysregulation vascularization hair loss skin repair cell-free delivery natural vesicles engineered vesicles hair growth skin healing
TLDR Bio-nanovesicles could improve hair and skin regeneration by delivering important molecules to repair and heal.
Bio-nanovesicles (BNVs), including natural exosomes and engineered nanovesicles, show significant promise for hair and skin regeneration by modulating key signaling pathways such as Wnt/β-catenin and PI3K/AKT. These vesicles enhance hair growth by promoting the transition of hair follicles from the telogen to anagen phase, increasing hair density and thickness, and preventing follicle miniaturization. BNVs also deliver therapeutic molecules like growth factors and miRNAs, which stimulate angiogenesis and repair processes, offering advantages over traditional therapies. Despite challenges in standardization and regulatory approval, ongoing clinical trials, including one with 12 participants, demonstrate their potential efficacy. BNVs also hold potential for treating skin conditions by reducing inflammation, promoting wound healing, and minimizing fibrosis.
