Bio-Nanovesicle-Based Approaches for Hair and Skin Regeneration: An Updated Concise Review
March 2026
in “
Cells
”
bio-nanovesicles BNVs hair regeneration skin regeneration miRNAs proteins growth factors extracellular vesicles exosomes microvesicles engineered nanovesicles Wnt/β-catenin pathway PI3K/AKT pathway MAPK/ERK pathway TGF-β/BMP pathway angiogenesis alopecia follicular miniaturization immune dysregulation vascularization hair loss skin repair cell-free delivery natural vesicles engineered vesicles hair growth skin healing
TLDR Bio-nanovesicles could improve hair and skin regeneration by delivering important molecules to repair and heal.
Bio-nanovesicles (BNVs) present a promising approach for hair and skin regeneration by offering a targeted, cell-free delivery system for miRNAs, proteins, and growth factors. These BNVs, which include natural extracellular vesicles like exosomes and microvesicles, as well as engineered nanovesicles, can modulate critical pathways such as Wnt/β-catenin, PI3K/AKT, MAPK/ERK, and TGF-β/BMP. This modulation can potentially restore regenerative crosstalk, enhance angiogenesis, and initiate repair processes in conditions like alopecia and chronic skin diseases, where conventional therapies are limited by factors such as follicular miniaturization, immune dysregulation, and impaired vascularization.
