Biofabrication of silver nanoparticles using Ostericum koreanum plant extract for treatment of allergic rhinitis in nursing care

The study explored the biofabrication of silver nanoparticles (Ag NPs) using Ostericum koreanum leaf extract, which were characterized by techniques like X-ray diffraction and UV-visible spectroscopy. These Ag NPs, sized 20-25 nm, inhibited inflammatory cytokines and mRNA expressions in human mast cell lines, indicating potential for treating allergic diseases mediated by mast cells. They also suppressed the activation of ERK, RIP2, and IKKβ, inhibiting caspase-1 and NF-κB, which are involved in inflammatory responses. The research emphasized the environmental benefits of using plant extracts for nanoparticle production, avoiding toxic chemicals used in traditional methods.