Bioinspired Antibacterial-Antioxidant Bioactive Hydrogel Synchronizes Immunomodulation-Microenvironment Remodeling for Infected Wound Regeneration
January 2025
in “
SSRN Electronic Journal
”
bioinspired hydrogel antibacterial-antioxidant hydrogel BD@HH6 bFGF photopolymerization tissue adhesion conductivity antioxidant activity ROS M2 macrophage polarization angiogenesis re-epithelialization ECM remodeling hair follicle regeneration basic fibroblast growth factor reactive oxygen species extracellular matrix
TLDR The hydrogel speeds up wound healing by fighting infections and supporting tissue repair.
The study presents a bioinspired antibacterial-antioxidant hydrogel (BD@HH6) designed to address chronic wound infections by synchronizing antimicrobial action with microenvironmental regulation. This hydrogel, created through photopolymerization and functionalized for controlled bFGF delivery, exhibits rapid gelation, strong tissue adhesion, and multifunctional properties such as conductivity and antioxidant activity. It effectively combats a broad spectrum of microbes and reduces oxidative damage by scavenging ROS and promoting M2 macrophage polarization. In murine models, BD@HH6 accelerated wound closure through mechanisms like angiogenesis, re-epithelialization, ECM remodeling, and hair follicle regeneration, offering a promising alternative to antibiotic-dependent treatments by integrating infection control with regenerative repair.
