Bioinspired Engineering of Polygonum Multiflorum Root Nanovesicles Regulates Dermal Papilla Cells In Vitro and Stimulates Human Hair Follicle Growth Ex Vivo

This study explores the use of nanovesicles derived from Polygonum multiflorum roots (PM-NVs) to enhance hair growth. PM-NVs were effectively internalized by human dermal papilla cells (DPCs), leading to increased DPC proliferation and activation of the β-catenin signaling pathway, which is essential for hair follicle regeneration. Ex vivo experiments demonstrated that PM-NVs promoted hair follicle elongation, indicating their potential as a natural and biocompatible treatment for alopecia. The findings suggest that PM-NVs could be a promising option for hair follicle regeneration and hair growth stimulation.