Biomaterial-Based Mechanical Regulation Facilitates Scarless Wound Healing With Functional Skin Appendage Regeneration

The document reviews the potential of biomaterial-based mechanical regulation to achieve scarless wound healing and regenerate functional skin appendages, such as hair follicles and sweat glands. It highlights how biomaterials with specific properties, like stiffness and topography, can influence cellular behavior and tissue regeneration by modulating mechanical signals and extracellular signaling. Key pathways, such as integrin-focal adhesion kinase (FAK) and the Hippo pathway, are crucial in this process. The review suggests that biomaterials can create optimal environments for tissue repair by preventing scarring and promoting cell differentiation and vasculogenesis. While many studies are still in early stages, advancements in technology are paving the way for improved wound healing strategies.