Biomechanical Factors in Psoriatic Disease: Defective Repair Exertion as a Potential Cause. Hypothesis Presentation and Literature Review

The document hypothesized that defective repair exertion due to biomechanical factors might have contributed to psoriatic disease. It highlighted the role of mechanical stress and repetitive microdamage in lesion development, particularly in areas of frequent movement or pressure. The study noted that over 50% of psoriasis patients experienced nail involvement, with trauma potentially contributing to specific nail lesions. It also discussed the impact of enthesitis and overweight on mechanical stress in psoriatic arthritis. The document reviewed the Wnt signaling system, particularly Wnt5a, in wound healing and psoriatic plaque formation, suggesting that psoriatic patients might be more vulnerable to chronic physical damage. However, it emphasized the need for more robust evidence to support these claims, especially regarding the disruption of the basement membrane laminin layer and the activation of mechanosensitive Wnt5a in psoriatic disease.