TLDR Biotinidase deficiency can cause symptoms like sleepiness, hair loss, and seizures.
The document reported a case study of a 5-year-old boy who was hospitalized due to symptoms including acute somnolence, alopecia, keratoconjunctivitis, and perioral stomatitis, which were associated with lactic acidaemia. The case highlighted the potential link between these symptoms and biotinidase deficiency, suggesting that this enzyme deficiency could lead to such clinical manifestations. The study underscored the importance of considering biotinidase deficiency in patients presenting with similar symptoms to ensure timely diagnosis and treatment.
November 2019 in “Harper's Textbook of Pediatric Dermatology” Understanding normal hair growth and loss in children is key to diagnosing and treating hair disorders.
82 citations
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August 2017 in “Cell Reports” An imbalanced gut and lack of biotin can cause hair loss in mice.
81 citations
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March 2009 in “Seminars in Cutaneous Medicine and Surgery” Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.
6 citations
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September 1996 in “Journal of the European Academy of Dermatology and Venereology” Biotin supplements may help hair regrowth in alopecia areata patients with low biotinidase activity.
1 citations
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September 1996 in “Journal of the European Academy of Dermatology and Venereology” Biotin supplements may help hair regrowth in some alopecia areata patients.
