Development and Optimization of Biotinoyl Tripeptide-1 Loaded Solid Lipid Nanoparticles for Protection Against Heat Induced Hair Damage

This study developed and optimized biotinoyl tripeptide-1 (BTP)-loaded solid lipid nanoparticles (SLNs) to protect hair from heat-induced damage. Using a Box-Behnken experimental design, the researchers optimized the formulation, achieving a particle size of 207.3 nm, a Polydispersity Index of 0.297, a zeta potential of -10.6 mV, and an entrapment efficiency of 46.2%. Hair samples treated with BTP-SLNs showed improved cuticle integrity, reduced microfibrillary separation, and increased resistance to thermal degradation compared to untreated samples. The study concluded that BTP-SLNs offer effective protection against heat damage by forming a lipid barrier and stabilizing the keratin matrix, making them a promising option for cosmetic hair care.