Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin: The Absence of Type VII Collagen Is Associated with Gelatinase-A (MMP2) Activity

February 2000 in “ Journal of Investigative Dermatology ”

Т. В. Карелина, G. A. Bannikov, Arthur Z. Eisen

type VII collagen Gelatinase-A MMP2 basement membrane zone extracellular matrix keratinocytes collagen matrix metalloproteinase 2

TLDR Type VII collagen absence helps skin development by allowing tissue remodeling.

The study examined the role of type VII collagen and Gelatinase-A (MMP2) in the development of human fetal skin appendages, using 76 fetal skin samples. It was observed that type VII collagen was absent at the basement membrane zone (BMZ) surrounding developing appendageal buds, despite the presence of its mRNA in adjacent keratinocytes. This absence was associated with the activity of Gelatinase-A, which facilitated the remodeling of the BMZ by degrading type VII collagen and other components, thus promoting tissue invasion and appendageal development. The findings underscored the collaborative role of epithelial and stromal cells in extracellular matrix turnover necessary for fetal skin morphogenesis.

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research The Appearance of Four Basement Membrane Zone Antigens in Developing Human Fetal Skin

65 citations , July 1984 in “Journal of Investigative Dermatology”

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