Bone Infarcts in a Woman With Systemic Lupus Erythematosus and Antiphospholipid Antibody Syndrome

February 2006 in “ Canadian Medical Association Journal ”

Soumya Chatterjee

systemic lupus erythematosus antiphospholipid antibody syndrome hair loss chronic steroid use mycophenolate mofetil prednisone hydroxychloroquine SLE APS steroid CellCept Plaquenil

TLDR A woman with lupus and antiphospholipid syndrome had bone damage, showing the need for careful treatment.

A 48-year-old woman with systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome presented with generalized pain, fatigue, and hair loss, among other symptoms. She had a history of immune thrombocytopenic purpura, deep venous thromboses, and pulmonary embolism. Radiographs and bone scans revealed multiple bone infarcts and avascular necroses. Her condition was attributed to SLE, antiphospholipid antibody syndrome, and chronic steroid use. Treatment included increasing her warfarin dose, starting mycophenolate mofetil for active SLE symptoms, and maintaining prednisone and hydroxychloroquine therapy. This regimen led to a reduction in pain and no further bone lesions.

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