Botulinum Toxin Type A for Preventing Facial Trauma and Hypertrophic Scars: A Meta-Analysis and Trial Sequential Analysis

    October 2025 in “ Journal of Cosmetic Dermatology ”
    Jie Lu, Yuhua Chen, Hong-Fu Xie, Yiming Wang
    TLDR Botulinum toxin Type A helps reduce hypertrophic scars and is generally safe.
    This meta-analysis, involving 644 patients across 12 randomized controlled trials, demonstrates that Botulinum Toxin Type A (BTX-A) significantly improves scar outcomes in the maxillofacial and cervical regions by reducing scar thickness, Vancouver Scar Scale scores, and pain/itch levels, while increasing patient satisfaction from 64% to 87%. The study confirms BTX-A's efficacy in preventing pathological scar formation through mechanisms like reducing muscle tension and modulating TGF-β1 signaling. Despite its effectiveness and minimal adverse effects, the study notes limitations such as small sample sizes and methodological issues, suggesting the need for more robust clinical guidance and further research to confirm long-term effects.
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