Botulinum Toxin Effects on Biochemical Biomarkers Related to Inflammation-Associated Head and Neck Chronic Conditions: A Systematic Review of Clinical Research
TLDR Botulinum toxin may reduce inflammation markers in head and neck conditions, but evidence is uncertain.
This systematic review evaluated the effects of Botulinum toxin type A (BoNT) on biochemical biomarkers in head and neck chronic conditions associated with inflammation. Nine studies were included, with concerns about bias in six. The most frequently studied biomarker was the calcitonin gene-related peptide (CGRP), followed by serotonin. Significant effects of BoNT were reported in six studies, including decreased plasma levels of CGRP in chronic migraine and trigeminal neuralgia, changes in serotonin levels, and alterations in oxidative stress and inflammatory markers. Despite these findings, the evidence was rated as very low to moderate certainty.
