Breezula, A Clinical Stage Topical Anti-Androgen, Promotes Dermal Papilla Inductivity And Reduces IL-6 Secretion In Balding Skin Samples Ex Vivo

    July 2025 in “ Journal of Investigative Dermatology ”
    A. Le Riche, P. Pallavi, Mara Gerloni, Gordon Alton, J. Edelkamp, Marta Bertolini
    TLDR Breezula® may be more effective than Minoxidil in promoting hair growth by reducing a hair growth inhibitor.
    The study investigates the efficacy of Breezula® (clascoterone 5% solution) compared to Minoxidil (5%) in treating male pattern hair loss (MPHL) using scalp biopsies from 5 patients. Both treatments enhanced alkaline phosphatase (AP) activity and hair matrix (HM) keratinocyte proliferation, which are associated with hair growth. Notably, Breezula® also reduced IL-6 secretion, a hair growth inhibitor, suggesting it may be more potent than Minoxidil in promoting hair growth. These findings indicate that Breezula® could restore dermal papilla (DP) inductivity and support hair growth, meriting further research.
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      community Clascoterone - what we have right now

      in Research/Science  10 upvotes 1 day ago
      Clascoterone is a topical treatment for androgenetic alopecia, showing modest to moderate hair regrowth, and may be available by 2027-2028. It is considered safer than finasteride, with discussions on its effectiveness compared to RU58841 and pyrilutamide.

      community Cosmo Pharma Lists Breezula Phase 3 Trial on ClinicalTrials.gov

      in Research/Science  25 upvotes 2 years ago
      A phase 3 trial for Breezula (clascoterone solution) to treat male pattern hair loss has been listed, with 726 participants and a completion date of January 2025. Other treatments mentioned include Aneira Pharma's combination of minoxidil and latanoprost, Triple Hair's combination of minoxidil, latanoprost, and finasteride, and a new microneedling and LLLT device called StimuSIL.

      community Minoxidil alone, 4 months consistent usage

      in Is this regrowth?  515 upvotes 5 months ago
      Minoxidil 5% foam was used twice daily for 4 months, resulting in visible hair regrowth. Users discussed adding finasteride for better long-term results, with concerns about its side effects and alternatives like breezula and clascoterone.

      community When is the cure gonna drop , how much more time

      in Research/Science  82 upvotes 1 day ago
      There is no imminent cure for hair loss, but treatments like Minoxidil, Finasteride, and new drugs such as KX-826, GT-20029, and PP405 are being explored. Current solutions focus on slowing hair loss and stimulating growth, with hopes for better options in the future.

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