Structure-Activity Relationship for Calanthoside, a Potential Hair Growth Stimulant with an Indole 2-S-,3-O-Bis-Glucoside Structure. Part 1: Role of Two Glucoside Moieties in Promoting HFDPC Proliferation

    January 2026 in “ RSC Medicinal Chemistry ”
    Riko Suzuki, Katsuki Takashima, Yoshiaki Mannse, H Nishikawa, Mina Ashidate, Shinsuke Marumoto, Fumihiro Ishikawa, Toshio Morikawa, Genzoh Tanabe
    This study investigates the potential of calanthoside, a compound with an indole 2-S-,3-O-bis-glucoside structure, as a hair growth stimulant. The research focuses on the role of its two glucoside moieties in promoting the proliferation of human follicle dermal papilla cells (HFDPC), which are crucial for hair growth. The findings suggest that these glucoside moieties are significant in enhancing HFDPC proliferation, indicating calanthoside's potential as a treatment for androgenetic alopecia (AGA). This study provides a foundation for further exploration of calanthoside as a novel therapeutic option for hair loss.
    Discuss this study in the Community →