Genetic Variant of the Canine FGF5 Gene for the Hair Length Trait in the Akita: Utility for Hair Coat Variations and Welfare in Conservation Breeding

    August 2025 in “ Genes
    Shinichiro Maki, Md Shafiqul Islam, Norio Kansaku, Nanami Arakawa, Akira Yabuki, Tofazzal Md Rakib, Abdullah Al Faruq, Osamu Yamato
    TLDR The FGF5 gene variant causes long hair in Akitas, and genetic testing is advised to manage coat length and welfare.
    The study identifies the FGF5:c.578C>T genetic variant as the cause of long hair in Akitas, inherited in an incompletely dominant manner. Analyzing DNA from 60 modern and 73 classic Akitas, researchers found a higher frequency of the T allele in modern Akitas (0.350) compared to classic ones (0.212). Breeders' preference for heterozygous C/T dogs, which have a fluffier coat, may increase the T allele frequency, leading to more long-haired Akitas that do not meet breed standards and may face welfare issues. The study recommends genetic testing to manage the T allele frequency, reduce long-haired births, and ensure the welfare and conservation of the breed.
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