Carcinogenesis of the Human Scalp. An Immunometabolic Centered View

This review explores the unique epidemiology of scalp skin cancer, particularly non-melanoma types, and suggests that hair presence offers protection not merely as a physical barrier but through IL-17 biased immunosurveillance. The loss of hair may lead to reduced immunosurveillance, facilitating the expansion of neoplastic cells and increasing the risk of skin cancer. Additionally, hair follicles and metabolic changes in the stroma contribute to an environment that promotes tumor growth. The insights from clinical observations could inform potential prevention and treatment strategies for cutaneous scalp neoplasia.