Causal Links Between 13 Autoimmune Diseases and Graft Dysfunction: A Mendelian Randomization Study

This Mendelian randomization study investigated the causal links between 13 autoimmune diseases and graft dysfunction. The study found that alopecia areata and asthma are linked to graft dysfunction, with alopecia areata showing a protective effect (odds ratio 0.828) and asthma showing a risk factor effect (odds ratio 1.79). Primary sclerosing cholangitis was identified as heterogeneous, but no heterogeneity or pleiotropy was observed in other autoimmune diseases. These preliminary findings suggest that alopecia areata and asthma may influence graft dysfunction, although the underlying mechanisms are not yet understood.