Participation of CD34-Enriched Mouse Adipose Cells in Hair Morphogenesis
February 2013
in “
Molecular Medicine Reports
”
TLDR CD34+ cells from fat tissue help form hair follicles and blood vessels in skin.
The study explored the involvement of CD34+ cells from mouse adipose tissue in hair follicle morphogenesis, using a model with GFP transgenic mice. CD34+ cells, when mixed with fetal mouse keratinocytes and dermal fibroblasts, significantly contributed to hair follicle formation by integrating into dermal sheath structures, unlike CD34- and unsorted SVF cells. These CD34+ cells also participated in blood vessel formation and demonstrated a strong potential for multi-lineage differentiation, suggesting they could be adipose-derived mesenchymal stem cells (ADMSCs) with enhanced differentiation capabilities. However, they were less potent than bone marrow stem cells in differentiating into multiple skin cell types, indicating differences in differentiation potential among adult stem cell types.
