Effective Role of Cytotoxic CD8+ T Cell in Iraqi Alopecia Areata Patients

The study on Iraqi patients with Alopecia areata (AA) involved 45 patients and 45 healthy controls, revealing significantly higher levels of circulating CD8+ T cells in patients (P < 0.05). It found a higher prevalence of AA in males (71.1%) compared to females (28.9%), particularly in individuals aged 21-30. The findings suggest that CD8+ T cells contribute to hair loss by disrupting the immune privilege of hair follicles, playing a direct role in the pathogenesis of AA.