Cell Death by Cornification

    June 2013 in “ Biochimica et biophysica acta. Molecular cell research ”
    Leopold Eckhart, Saskia Lippens, Erwin Tschachler, Wim Declercq
    TLDR Cornification is how skin cells die to form the protective outer layer of skin, hair, and nails.
    The document reviewed the process of cornification, a unique form of programmed cell death in keratinocytes essential for forming the skin barrier, hair, and nails. It highlighted the roles of various enzymes, including caspase-14, DNase1L2, and cathepsins, in the differentiation and maturation of keratinocytes. The review emphasized the anti-apoptotic and anti-necrotic mechanisms that prevent premature cell death, ensuring a resilient and interconnected barrier. Despite advances, many mechanistic aspects of keratinocyte death during cornification remained unclear, underscoring the need for further research to fully understand this complex process and its implications for skin conditions and cancer.
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