Cellular Senescence and Polycystic Ovary Syndrome: Mechanisms and Therapeutic Strategies from a New Perspective
December 2025
in “
Annals of Medicine
”
cellular senescence polycystic ovary syndrome PCOS replicative senescence stress-induced premature senescence immunoinflammatory responses cell cycle arrest oxidative stress DNA damage follicular development senolytic drugs senomorphic drugs hyperandrogenic insulin-resistant senescence anti-senescence therapies
TLDR Targeting senescent cells may offer new treatments for PCOS.
This review explores the complex relationship between cellular senescence and polycystic ovary syndrome (PCOS), highlighting how mechanisms like replicative senescence, stress-induced premature senescence, and immunoinflammatory responses contribute to PCOS. Key features of senescence, such as cell cycle arrest, oxidative stress, and DNA damage, are linked to impaired follicular development and increased pregnancy complications in PCOS patients, particularly those who are obese, hyperandrogenic, or insulin-resistant. The study suggests that senolytic and senomorphic drugs, which target senescent cells and their effects, could be promising treatments for PCOS. Understanding these mechanisms may offer new insights into PCOS pathogenesis and support the development of anti-senescence therapies.
