TLDR A new method accurately measures clobetasol propionate in hair and skin.
The study developed a simple HPLC-UV method for quantifying clobetasol propionate (CLO) in hair follicles and different skin layers, addressing the need for precise drug delivery in alopecia treatment. Using a RP-C18 column and a specific mobile phase, the method achieved CLO elution at 10.1 minutes with high resolution from skin matrix interferences. Validation followed International Conference on Harmonization guidelines, ensuring selectivity, linearity (0.5–15.0 μg/mL), robustness, precision, accuracy, and detection limits (0.02 and 0.07 μg/mL). The method was successfully applied in in vitro skin permeation and hair follicle deposition experiments, proving its effectiveness for CLO quantification.
69 citations
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December 2015 in “Journal of Controlled Release” Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.
26 citations
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March 2015 in “American journal of clinical dermatology” Topical clobetasol is recommended over mycophenolate mofetil for treating Lichen Planopilaris due to better safety and patient satisfaction.
77 citations
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January 2015 in “International Journal of Biological Macromolecules” Chitosan nanoparticles improve minoxidil delivery to hair follicles for better alopecia treatment.
102 citations
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April 2014 in “International Journal of Dermatology” The treatment helped reduce symptoms and stabilize the hairline in most patients with Frontal Fibrosing Alopecia, but hair regrowth was limited.
49 citations
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November 2013 in “JAMA dermatology” Clobetasol propionate, 0.05%, is more effective and safe for treating childhood alopecia areata than hydrocortisone, 1%.
13 citations
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July 2011 in “Journal of Dermatological Treatment” Clobetasol and pimecrolimus are similarly effective for alopecia areata, but pimecrolimus has fewer side effects and is preferred for long-term use.
