Citrus Limon-Derived Extracellular Vesicles Promote Hair Growth

May 2026 in “ Applied Biochemistry and Biotechnology ”

Fatemeh Raoufimanesh, Seyed Mohammad Atyabi, Marjan Mohamadali, Zeinab Alsadat Mirshaby, Shiva Irani, Rassoul Dinarvand

Citrus limon-derived extracellular vesicles hair follicle environment hair follicle development hair follicle cycling lemon-derived EVs hair growth

TLDR Lemon-derived vesicles may help hair grow.

The study explores the use of Citrus limon-derived extracellular vesicles (EVs) in promoting hair growth. It concludes that these vesicles can positively influence the hair follicle environment, suggesting their potential as a natural treatment for hair loss. The research indicates that Citrus limon-derived EVs may stimulate hair growth by modulating biological pathways related to hair follicle development and cycling.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

18 / 18 results

research The Skin Microenvironment: A Dynamic Regulator of Hair Follicle Development, Cycling, and Disease

September 2025 in “Biomolecules”

The skin microenvironment significantly affects hair growth and loss, offering potential treatment avenues.

research The Roles of Exosomes in Regulating Hair Follicle Growth

July 2024 in “Clinical Cosmetic and Investigational Dermatology”

Exosomes can help promote hair growth and may treat hair loss.

research Wound-Induced Hair Follicle Neogenesis as a Promising Approach for Hair Regeneration

August 2023 in “Molecules and Cells”

Hair can regrow after significant damage through a process similar to how it forms before birth, involving stem cells and various cell types and signals. This could be a new way to prevent scarring and promote hair growth.

research Garlic Exosomes Promote Hair Growth Through the Wnt/Beta-Catenin Pathway and Growth Factors

July 2023 in “Cureus”

Garlic can help hair grow by activating certain growth pathways, and it works whether you eat it or apply it to your scalp.

research Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities

12 citations , April 2022 in “Journal of cosmetic dermatology”

Exosome therapy could help with hair loss, but more research is needed to confirm its safety and effectiveness.

research Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cells

9 citations , June 2020 in “Tissue Engineering and Regenerative Medicine”

HHORSC exosomes and PL improve hair growth treatment outcomes.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research Macrophage-Derived Extracellular Vesicle Promotes Hair Growth

51 citations , April 2020 in “Cells”

Special cell particles from macrophages can help hair grow.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

69 citations , April 2019 in “Biomedicines”

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , March 2019 in “Experimental Dermatology”

Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.

research Skin Cell Heterogeneity in Development, Wound Healing, and Cancer

211 citations , May 2018 in “Trends in cell biology”

Different types of skin cells play specific roles in development, healing, and cancer.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , April 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

113 citations , November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention

research Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations , March 2003 in “American Journal of Pathology”

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.