Clinical Assessment of CL22209, a Standardized Proprietary Extract of Asparagus Racemosus, for Mitigating Vasomotor and Menstrual Symptoms in Perimenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Study

    July 2025 in “ Functional Foods in Health and Disease ”
    Poonam Yadav, Sanjay Yadav, Sai Sarada Vedururu, Gayatri Kiumari
    TLDR CL22209, an Asparagus racemosus extract, safely reduces perimenopausal symptoms and balances hormones.
    The study evaluated the efficacy and safety of CL22209, a standardized extract of Asparagus racemosus, in alleviating vasomotor and menstrual symptoms in 75 early perimenopausal women over 120 days. Participants received either 50 mg or 100 mg of CL22209 or a placebo. Results showed significant reductions in Menopausal Rating Scale scores and Hot Flash Weekly Weighted Scores, with improvements in menstrual symptoms and hormonal regulation. The extract demonstrated a dose-dependent effect on hormone levels and was well-tolerated with no serious adverse events. CL22209 is positioned as a promising natural intervention for perimenopausal symptom relief and hormonal balance.
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