Clinical translational research on stem cell products: prospects and challenges

    Shuang Chen, Lin ZHANG, Yushuang Ren, Xue Bai, Xiao Wei, Maoyue Chai, 崔苏甦, Xinran Zhao, Hongxin Deng
    TLDR Stem cell therapy shows promise but needs better safety and quality standards.
    Stem cell therapy is promising for treating resistant diseases, but its clinical application faces challenges. This review analyzes global stem cell trials and products, highlighting the need for standardized production and quality assurance to ensure safety and efficacy. It suggests strategies to improve stem cell product efficacy and safety, addressing issues like heterogeneity, administration methods, and genetic modifications. Multidisciplinary cooperation and innovative research are essential to expand therapeutic applications and advance regenerative medicine.
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