TLDR Hair changes and a high occipital hairline may help diagnose Trichorhinophalangeal Syndrome.
This multicenter retrospective study on Trichorhinophalangeal Syndrome (TRPS) highlights the significance of hair alterations in diagnosis, using trichoscopy as a key tool. The study observed a normal hair diameter relationship (frontal ≥ occipital) in females, while a male patient showed frontal-occipital inversion. It suggests that low hair density in TRPS may be due to an increased number of single hair units rather than follicular distance. Additionally, a high occipital hairline is proposed as a potential diagnostic feature, though further studies are needed to confirm these findings.
1 citations
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January 2020 in “Skin appendage disorders” A family was found with both Trichorhinophalangeal syndrome and Loose Anagen Syndrome, suggesting a genetic connection.
41 citations
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May 2001 in “PubMed” Different thicknesses of hair strands can indicate the severity of hair thinning.
83 citations
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April 1999 in “Dermatologic Surgery” The research found that for a typical hair density, about 11 square centimeters of donor scalp is needed to get 800 hair grafts for transplantation.
1 citations
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January 2020 in “Skin appendage disorders” A family was found with both Trichorhinophalangeal syndrome and Loose Anagen Syndrome, suggesting a genetic connection.
6 citations
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January 2015 in “Journal of The European Academy of Dermatology and Venereology” Different hair loss types need accurate diagnosis for proper treatment.
4 citations
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January 2018 in “Annals of dermatology/Annals of Dermatology” Hair transplantation successfully treated hair loss in a patient with Trichorhinophalangeal syndrome.
68 citations
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August 2012 in “Journal of the American Academy of Dermatology” Dermatoscopy is a useful tool for diagnosing hair disorders and can help choose samples for more detailed analysis.
26 citations
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July 2019 in “Dermatology and Therapy” The conclusion is that genetic testing is important for diagnosing and treating various genetic hair disorders.
