Collagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels -A Narrative Review.

This narrative review examines the benefits of collagen, curcumin, and glutathione supplementation for enhancing dermal health in aging women with declining estrogen levels. It highlights that oral collagen, supported by 23 clinical studies from 2020 to 2025, significantly improves skin parameters such as elasticity, hydration, and wrinkle reduction. Studies, including those with 60, 50, and 100 women, consistently show collagen's effectiveness, though its impact on hair and nails is less explored. Curcumin and glutathione, known for their antioxidant properties, also show promise in improving skin health, but more research is needed to determine optimal dosing and combinations. The review underscores the importance of lifestyle factors and the need for standardized measurements in clinical trials to enhance treatment evaluation for estrogen-deficient skin.