Enhancing Dermal Collagen Density Towards Youthfulness: A Comparative Study of PCL, PLLA, and PDO Thread Implantation in Aging Rats Model
January 2025
in “
PubMed
”
TLDR PCL threads are most effective for youthful skin by boosting collagen.
This study investigated the effectiveness of polydioxanone (PDO), poly-lactic acid (PLLA), and polycaprolactone (PCL) threads in enhancing dermal collagen density and reversing signs of aging in UVB-exposed aging model rats. The results showed that all three types of threads improved skin quality by increasing dermal collagen density, reducing the COL1/COL3 ratio, and enhancing COL3A1 gene expression, making the skin appear more youthful. Among the threads tested, PCL was found to be the most effective in achieving these outcomes. The study concludes that thread implantation can support skin anti-aging by promoting a youthful collagen profile.
