Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease

The document reviewed the role of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in skin health and disease, highlighting its involvement in keratinocyte differentiation, sebocyte differentiation, hair follicle growth, and wound healing. PPAR β/δ was implicated in inflammatory skin diseases like psoriasis and acne vulgaris, with its modulation offering potential therapeutic strategies. It played ambivalent roles in skin cancer, acting as a tumor growth modifier with context-specific effects. The research emphasized PPAR β/δ as a significant target for understanding and treating various skin conditions, although further research was needed to fully understand its complex functions and context-specific activities.