Triple-Layered Core-Shell Fiber Dressings with Enduring Platelet Conservation and Sustained Growth Factor Release Abilities for Chronic Wound Healing

January 2024 in “ Regenerative Biomaterials ”

Simin Lai, Tingbin Wu, Chenxi Shi, Xiaojing Wang, Pengbi Liu, Lihuan Wang, Hui Yu

platelet-rich plasma growth factors core-shell fibers coaxial bioprinting freeze-drying chronic wound healing regenerative medicine PRP

TLDR The new dressing improves chronic wound healing by preserving and releasing growth factors effectively.

This study presents a novel multifunctional dressing using triple-layered core-shell fibers to enhance the preservation and sustained release of platelet-rich plasma (PRP) for chronic wound healing. Utilizing a one-step coaxial bioprinting technique combined with freeze-drying, the dressing effectively disperses and immobilizes platelets in the core layer, allowing controlled release of growth factors and reducing PRP deactivation during storage. The dressing maintains PRP activity for up to 180 days, optimizing conditions for freeze-drying and storage, and offers a promising solution for improving the therapeutic effects of PRP in regenerative medicine.

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research Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma for Treating Androgenic Alopecia

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