Efficacy of Cosmerna ARI in Improving Androgenetic Alopecia in Europeans: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial Over 6 Months

December 2025 in “ Clinical & Experimental Dermatology and Therapies ”

Cosmerna ARI SAMIRNA-AR68 androgenetic alopecia AGA terminal hair density vellus hair density

The study assessed the efficacy of Cosmerna ARI, containing SAMIRNA-AR68, in treating androgenetic alopecia (AGA) among 120 European participants over 6 months, with a final analysis of 41 subjects. The treatment group experienced a 48% reduction in hair loss and an increase in terminal hair density from 99.7 to 127.8, both statistically significant with p-values less than 0.01. Vellus hair density improved but not significantly compared to the control group. No adverse skin effects were reported, indicating that Cosmerna ARI is a safe and effective treatment for AGA in Europeans, aligning with previous results in Korean patients. The study highlights Cosmerna ARI as a promising alternative for AGA treatment, with the convenience of weekly applications.

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