COVID-19: Pulmonary and Extra Pulmonary Manifestations

The document reviewed the diverse manifestations of COVID-19, emphasizing its impact as a multisystem disease beyond just respiratory symptoms. Pulmonary effects ranged from mild to severe, including ARDS, while extrapulmonary symptoms affected the cardiovascular, gastrointestinal, renal, neurological, psychiatric, dermatological, ocular, endocrine, and musculoskeletal systems. The virus's interaction with ACE2 receptors in various organs was a key factor in these manifestations. The study highlighted the influence of factors like viral load, comorbidities, age, sex, and genetic predispositions on disease severity. Management strategies varied, with treatments like remdesivir and dexamethasone used for severe cases, and the importance of considering extrapulmonary symptoms for early diagnosis was emphasized. The document also discussed the potential for reinfection and the persistence of viral RNA post-recovery.