In Vivo Evaluation of Cromolyn Sodium Topical Gels for the Treatment of Atopic Dermatitis
TLDR Cromolyn sodium oleate gel is more effective and safer for treating atopic dermatitis than dexamethasone.
This study evaluated the efficacy of cromolyn sodium (CS) topical gels for treating atopic dermatitis (AD) in a mice model, comparing it to a topical corticosteroid, dexamethasone. Two 4% CS gels were formulated, with the oleate gel showing superior permeation and skin retention. In a 3-week study involving four groups of six mice, the CS oleate gel demonstrated the highest scab reduction (78.48% ± 25.00%) and complete healing in 2 mice, outperforming both the DNCB group (53.95% ± 19.31%) and the dexamethasone group (33.05% ± 13.99%). The dexamethasone group experienced adverse effects such as skin atrophy, lesions, hair loss, and weight loss. The CS oleate gel was found to be a more effective and safer treatment for AD than dexamethasone, providing significant healing with fewer side effects.
