Editorial: Crosstalk: Skin Cells and Immune Cells in Inflammatory Skin Diseases

This editorial discusses the complex interactions between skin cells and immune cells in inflammatory skin diseases such as psoriasis and atopic dermatitis (AD). It highlights the role of the epithelial–immune microenvironment (EIME) in providing defense and protective responses through barriers, innate immunity, and acquired immunity. The article emphasizes the importance of understanding these interactions to develop targeted therapies. It also explores the role of cytokines, toll-like receptors, and genetic factors in the pathogenesis of these diseases. Novel treatments targeting specific immune signals have shown promise in managing these conditions. Additionally, the editorial discusses the systemic implications of psoriasis and the potential for therapeutic interventions in co-occurring conditions like non-alcoholic steatohepatitis (NASH). Understanding the crosstalk between skin and immune cells is crucial for advancing treatment strategies for inflammatory skin diseases.