Synthesis of Cu4O3 Nanoparticles Using Pumpkin Seed Extract: Optimization, Antimicrobial, and Cytotoxicity Studies

    January 2025 in “ Nanotechnology Reviews ”
    Azhar U. Khan, Azmat Ali Khan, Nazia Malik, Jun Her, Mona Gupta, Subhranshu Panda, Khalid Imtiyaz, M. Moshahid A. Rizvi, Mohammed Mushtaque, Sudhakar Bansod, Masita Mohammad, Min Kim, Kyungsoo Pyo, Mahboob Alam
    TLDR Pumpkin seed extract can create copper oxide nanoparticles with potential antibacterial and cancer-fighting properties.
    This study explores a green synthesis method for copper oxide (Cu4O3) nanoparticles using pumpkin seed extract, which acts as both a reducing and stabilizing agent. The nanoparticles, sized between 8.92 and 55.84 nm, were characterized by various techniques and showed a maximum yield of 89.87% under optimized conditions. They exhibited significant antibacterial activity against Bacillus subtilis and moderate cytotoxic effects on lung and colon cancer cell lines. Computational studies revealed a moderate HOMO–LUMO energy gap, suggesting potential interactions with biological systems. These results highlight the potential biomedical applications of these eco-friendly nanoparticles.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results