Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Curcumin's low solubility and bioavailability limit its use as a free drug, but nanoformulations can enhance its effectiveness in wound healing by improving bioavailability and promoting processes like angiogenesis and collagen synthesis. Various nanoformulations, such as nanofibers, nanoparticles, and nanoliposomes, have been developed to ensure controlled release of curcumin, maintaining its presence throughout the healing process. For instance, curcumin-loaded chitosan nanoparticles in nanofibers can release 80% of curcumin over 10 days, supporting sustained healing. Additionally, porous structures like sponges and aerogels mimic the extracellular matrix, aiding cell attachment and nutrient flow, which are crucial for effective wound healing.