TLDR A new mouse mutation causes skin and hair issues, influenced by another gene.
The study identified a new mouse mutation called "curly bare" (cub) on chromosome 11, which caused skin and hair abnormalities. Additionally, a modifier gene (mcub) on chromosome 5 was found to influence the expression of these abnormalities. The research provided insights into the genetic basis of hair and skin conditions, although it was conducted on mice and may not directly translate to humans. The findings contributed to the understanding of genetic interactions affecting hair and skin phenotypes.
135 citations
,
May 1994 in “Medical Entomology and Zoology” Mouse models help study genetic skin diseases.
578 citations
,
April 1993 in “Cell” TGFα gene mutation in mice causes abnormal skin, wavy hair, curly whiskers, and sometimes eye inflammation.
2 citations
,
June 2023 in “Journal of cell science” Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.
22 citations
,
July 2016 in “Cellular and Molecular Life Sciences” Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.
10 citations
,
December 2021 in “Frontiers in cell and developmental biology” The research identified genes that explain why some sheep have curly wool and others have straight wool.
7 citations
,
November 2014 in “Histochemistry and Cell Biology” The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.
86 citations
,
December 2001 in “Experimental dermatology” Mutant mice help researchers understand hair growth and related genetic factors.