Cutaneous Clues in Systemic Disease: The Role of Dermatological Manifestations in Internal Medicine and Endocrinology
June 2026
in “
IECCMEXICO
”
acanthosis nigricans xerosis pigmentation changes vascular lesions endocrine-metabolic disorders diabetes mellitus thyroid dysfunction autoimmune diseases renal conditions hepatic conditions paraneoplastic dermatoses skin dryness skin discoloration vascular skin changes thyroid problems liver conditions kidney conditions
TLDR Skin changes can indicate underlying health issues like diabetes or thyroid problems.
This review highlights the diagnostic value of dermatological manifestations as indicators of systemic diseases in internal medicine and endocrinology. It emphasizes that skin findings, such as acanthosis nigricans, xerosis, pigmentation changes, and vascular lesions, are frequently associated with endocrine-metabolic disorders like diabetes mellitus and thyroid dysfunction. Autoimmune diseases, renal and hepatic conditions, and paraneoplastic dermatoses also show characteristic skin patterns linked to systemic issues. The review underscores the importance of dermatological examination in medical practice for improving diagnostic accuracy, facilitating early intervention, and enhancing interdisciplinary collaboration, reinforcing the skin's role as a reflection of systemic health.
