TLDR Cyclosporin A helps hair grow by increasing certain growth factors.
The study investigated the effects of cyclosporin A on hair growth by examining mRNA expressions of HGF and VEGF in cultured mouse vibrissa follicles. Using RT-PCR and semi-quantitative RT-PCR, it was found that on the sixth day of culture, the expressions of HGF and VEGF mRNA were still detectable in the follicles treated with cyclosporin A, unlike in the control group. This indicated that cyclosporin A upregulated the mRNA expression of these growth factors, suggesting a mechanism by which it stimulated hair growth.
11 citations
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September 2012 in “Journal of Nanjing Medical University” Cyclosporine A was found to increase hair growth in mouse whisker follicles.
155 citations
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August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution” Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.
10 citations
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January 2009 in “Elsevier eBooks” Hair growth is influenced by hormones and goes through different phases; androgens can both promote and inhibit hair growth depending on the body area.
49 citations
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March 2014 in “Journal of Investigative Dermatology” Using the drugs AMD3100 and Tacrolimus together greatly improves skin healing and hair growth after a deep skin cut by increasing stem cells in the wound.
2 citations
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January 2014 in “Hair therapy & transplantation” New treatments for hair growth disorders are needed due to limited current options and complex hair follicle biology.