Cytopathological Evaluation of Vaginal Mucosa in Mice Treated with an Antiandrogenic

The study evaluated the cytopathological effects of short-term flutamide treatment on the vaginal mucosa of mice, given its use by women in Brazil for conditions like acne, alopecia, and hirsutism. Flutamide, a non-steroidal antiandrogen, blocks androgen receptors and affects testosterone and DHT metabolism. The research found no significant changes in the estrous cycle phases of treated mice, but suggested further studies are needed to conclusively determine any effects, considering factors like treatment duration and dosage.