DataSheet5_BBS7–SHH Signaling Activity Regulates Primary Cilia for Periodontal Homeostasis.csv
December 2021
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5 / 1000+ resultsresearch Video2_BBS7–SHH Signaling Activity Regulates Primary Cilia for Periodontal Homeostasis.MP4
December 2021 in “Figshare”research Video3_BBS7–SHH Signaling Activity Regulates Primary Cilia for Periodontal Homeostasis.MP4
December 2021 in “Figshare”research DataSheet3_BBS7–SHH Signaling Activity Regulates Primary Cilia for Periodontal Homeostasis.csv
December 2021 in “Figshare” BBS7 is crucial for maintaining healthy gums by regulating important signaling pathways.
research DataSheet2_BBS7–SHH Signaling Activity Regulates Primary Cilia for Periodontal Homeostasis.csv
December 2021 in “Figshare” The study investigated the role of Bardet-Biedl syndrome 7 (BBS7) in maintaining periodontal ligament (PDL) homeostasis under occlusal hypofunction conditions. RNA sequencing of 34 human teeth revealed that BBS7 expression was downregulated in hypofunctional PDL, leading to atrophic changes such as reduced PDL cell numbers, altered collagen fiber alignment, and decreased blood vessel diameter. The study found that Sonic hedgehog (Shh) signaling activity was closely linked to BBS7 expression, and BBS7 knockdown suppressed cell migration and angiogenesis in vitro. These findings suggested that BBS7 was crucial for maintaining Shh signaling and PDL homeostasis.
research DataSheet1_BBS7–SHH Signaling Activity Regulates Primary Cilia for Periodontal Homeostasis.csv
December 2021 in “Figshare” BBS7 is crucial for maintaining periodontal health by supporting Shh signaling.