Decreased Gas6 and sAxl Plasma Levels Are Associated with Hair Loss in COVID-19 Survivors

    Daria Apostolo, Davide D’Onghia, Stelvio Tonello, Rosalba Minisini, Alessio Baricich, Carla Gramaglia, Filippo Patrucco, Patrizia Zeppegno, Antonio Acquaviva, Piero Emilio Balbo, Luigi Mario Castello, Giuseppe Cappellano, Annalisa Chiocchetti, Chiara Gerevini, Mara Giordano, Fatiha Laaguid, Marcello Manfredi, Davide Raineri, Cristina Rigamonti, Roberta Rolla, Valentina Romano, Marco Confalonieri, Paola Savoia, Elisa Zavattaro, Mario Pirisi, Barbara Ruaro, Pier Paolo Sainaghi, Mattia Bellan
    TLDR Lower Gas6 and sAxl levels are linked to hair loss in COVID-19 survivors.
    In a study involving 263 COVID-19 survivors, researchers found that decreased plasma levels of Growth Arrest-Specific 6 (Gas6) and its soluble receptor Axl (sAxl) were associated with hair loss. Of the participants, 69 (26.2%) experienced hair loss, with Gas6 and sAxl levels, along with female sex, being independent predictors. Although most cases resolved spontaneously, 23.7% of subjects reported persistent hair loss one year post-discharge. The study highlights the potential role of Gas6 and sAxl in post-COVID-19 hair loss.
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