Depression and anxiety, peripheral blood inflammatory factors, and stress levels on therapeutic outcomes in patients with chronic wounds

This study investigated the impact of depression, anxiety, peripheral blood inflammatory factors, and stress levels on the therapeutic outcomes of 110 patients with chronic wounds. The results showed that 95 patients experienced effective treatment outcomes, while 15 did not. Significant differences were found between the effective and ineffective groups in terms of wound area, infection status, daily bed time, and scores on the Hamilton Anxiety and Depression Rating Scales, as well as levels of interleukin-6, tumor necrosis factor-alpha, and superoxide dismutase. Logistic regression identified wound area ≥ 7 cm², HAMA ≥ 9, and HAMD ≥ 8 as independent risk factors for ineffective treatment. The study concludes that wound size, anxiety, and depression significantly influence therapeutic outcomes, highlighting the need for targeted strategies to address these factors.