Dermo-Follicular Proliferation Induced by Paclitaxel and Counteracted by Minoxidil in Mice

The study investigated the effects of Paclitaxel-induced alopecia in mice and evaluated the efficacy of Minoxidil and a solvent mixture (Ethanol:PEG:Water) in counteracting hair loss. Paclitaxel, a chemotherapy drug, caused hair follicle miniaturization and inhibited hair growth, leading to alopecia. Minoxidil, known for its vasodilating properties, helped stop hair loss and promoted hair follicle proliferation by improving blood and nutrient flow to the follicles. The solvent mixture also prevented alopecia when administered with Paclitaxel. Both visual observations and quantitative data, such as the A/T ratio and follicular density, supported the inhibition of alopecia by these treatments.