Dexpanthenol Ameliorates Lipopolysaccharide-Induced Cardiovascular Toxicity by Regulating the IL-6/HIF1α/VEGF Pathway

    January 2024 in “ Heliyon ”
    Mustafa Soner Özcan, Mehtap Savran, Duygu Kumbul Doğuç, Hatice Kübra Doğan, Melike Altıntaş, Samet Coşan
    TLDR Dexpanthenol helps protect the heart from damage by reducing inflammation and stress.
    The study demonstrates that Dexpanthenol (Dex) treatment provides a protective effect against lipopolysaccharide (Lps)-induced cardiovascular toxicity in rats. This is achieved by reducing inflammation, oxidative stress, and apoptosis, which are key contributors to cardiac and endothelial damage. The protective mechanism involves the regulation of the IL-6/HIF1α/VEGF pathway, highlighting Dex's potential therapeutic role in managing cardiovascular damage induced by Lps.
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