Role of Dehydroepiandrosterone in the Pathophysiology and Clinical Manifestations of Polycystic Ovary Syndrome

January 2025 in “ International Journal of Forest Animal and Fisheries Research ”

Anoop Kumar Shukla, Sneha Verma, Ramakant Yadav, Ambuj Mishra, Kesar Farzana

Dehydroepiandrosterone DHEA DHEAS Polycystic Ovary Syndrome PCOS hyperandrogenism hormonal implications metabolic implications neuroendocrine implications ovarian function biomarker diagnostic criteria

TLDR DHEA may play a complex role in PCOS, affecting hormones, metabolism, and symptoms.

This review explores the role of Dehydroepiandrosterone (DHEA) in the pathophysiology of Polycystic Ovary Syndrome (PCOS), highlighting its hormonal, metabolic, and neuroendocrine implications. Elevated levels of DHEA and its sulfated form (DHEAS) are found in some women with PCOS, particularly those with hyperandrogenism, although study results are inconsistent due to varying diagnostic criteria and methodologies. DHEA influences ovarian function, metabolic status, and neuropsychological symptoms, indicating its multifactorial role in PCOS. It may act as both a biomarker and a mechanistic factor in PCOS, but standardized measurement protocols and detailed phenotypic analyses are needed to clarify its diagnostic and therapeutic significance.

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